|
KMID : 0359919920110020101
|
|
Korean Journal of Nephrology
1992 Volume.11 No. 2 p.101 ~ p.114
|
|
|
Immunologic and Morphologic Study of Experimental IgA Nephropathy in ddY Mice after Administration of Cyclosporin A(CsA)
|
|
|
|
|
Abstract
|
|
|
Ddy mice have been reported as a spontaneous animal model of IgA nephropathy after 40 weeks of age. To investigate the role of T lymphocyte in the pathogenesis of IgA nephropathy, we administered CsA(20 mg/kg) to 9 week old ddY mice
intraperitoneally
every other day until killed. Fifty ddY mice were divided into 2 groups as natural course group (NCG) and CsA injected group (CsAN). At 10, 17, 27 and 40 weeks of age 5 ddy mice of each groups were sacrificed. At 40 weeks of age, serum IgA level
of
both
groups were increased, and CD3+ and CD4+ T lymphocyte were increased in NCG but were markedly decreased in CsAN compared to those of 10 weeks of age. In CsAN serum IgA level were lower than those of NCG. Histologically proliferation of measngial
cells
with increased mesangial matrix were observed in both groups but these changes were noted more prominant and frequent in CsAN. IF and EM findings also revealed the same results. These data suggest that decrease of CD4+ T lymphocyte may involve
the
inhibition of increase serum IgA level, but it seems that serum IgA level has no correlation with the histopathologic alterations in ddY mice.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|